abstract：:During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocyti...

journal_title：Journal of clinical medicine

authors： Meyer MM,Brandenburg L,Hudel H,Agné A,Padberg W,Erdogan A,Nef H,Amati AL,Dörr O,Witte B,Grau V

更新日期：2020-10-18 00:00:00

abstract：:Differentiation syndrome (DS) is a potentially fatal adverse drug reaction caused by the so-called differentiating agents such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), used for remission induction in the treatment of the M3 subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL...

journal_title：Journal of clinical medicine

authors： Gasparovic L,Weiler S,Higi L,Burden AM

更新日期：2020-10-18 00:00:00

abstract：:Here we describe our modified surgical technique of bilateral pubococcygeus plication (BPCP) for cystocele repair and assess its safety and long-term outcomes. This is a prospective study of 147 consecutive women who underwent BPCP for cystocele between January 2010 to January 2018. Inclusion criteria was naïve women ...

journal_title：Journal of clinical medicine

authors： Balzarro M,Rubilotta E,Antonelli A

更新日期：2020-10-16 00:00:00

abstract：:Cardiovascular autonomic neuropathy (CAN) is a common complication of diabetes mellitus. Cardiovascular reflex tests (CARTs) are the gold standard in the diagnosis of CAN, but the handgrip test is no longer recommended to be performed. Previously, the inverse association between the presence of hypertension and handgr...

journal_title：Journal of clinical medicine

authors： Kempler M,Hajdú N,Putz Z,Istenes I,Vági O,Békeffy M,Schnabel K,Kempler P,Körei AE

更新日期：2020-10-16 00:00:00

abstract：:Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have been effective in only a small subset of patients and a principal mechanism underlying immune-refractoriness is a 'cold' tumour microenvironment, that is, lack of a T-cell-rich, spontaneously inflamed phenotype. As such, there is...

journal_title：Journal of clinical medicine

authors： Motedayen Aval L,Pease JE,Sharma R,Pinato DJ

更新日期：2020-10-16 00:00:00

abstract：:Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology is characterized by a significant cell response to injury and gene expression. No study investigating changes in expression of those genes associated with collagen regeneration and remodeling of extrac...

journal_title：Journal of clinical medicine

authors： Sánchez-Sánchez JL,Calderón-Díez L,Herrero-Turrión J,Méndez-Sánchez R,Arias-Buría JL,Fernández-de-Las-Peñas C

更新日期：2020-10-15 00:00:00

abstract：:Studies have reported controversial findings on the association between fetal growth restriction (FGR) or intertwin weight discordance and the risk of hypertensive disorders of pregnancy (HDP) in twin pregnancies. The aim of this study was to investigate the association between twin growth disorders and HDP. Twin preg...

journal_title：Journal of clinical medicine

authors： Giorgione V,Bhide A,Bhate R,Reed K,Khalil A

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:In late December 2019, a new pandemic caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection began to spread around the world. The new situation gave rise to severe health threats, economic uncertainty, and social isolation, causing potential deleterious effects on people's phys...

journal_title：Journal of clinical medicine

authors： Emodi-Perlman A,Eli I,Smardz J,Uziel N,Wieckiewicz G,Gilon E,Grychowska N,Wieckiewicz M

更新日期：2020-10-12 00:00:00

abstract：:In excess of three quarters of patients with psoriatic arthritis (PsA) have preceding psoriasis (PsO), which offers a clinical biomarker for the recognition of early PsA. Numerous surveys have shown a remarkably high frequency of clinically occult musculoskeletal symptoms in psoriasis patients. Imaging studies, partic...

journal_title：Journal of clinical medicine

authors： Savage L,Tinazzi I,Zabotti A,Laws PM,Wittmann M,McGonagle D

更新日期：2020-10-12 00:00:00

abstract：INTRODUCTION:Cardiovascular risk factors, pre-existing comorbidities, molecular factors, and the direct effects of second- and third-generation BCR-ABL1 tyrosine kinase inhibitors on the vascular endothelium contribute to the progression of cardiovascular (CV) events, especially atherothrombotic conditions. The study o...

journal_title：Journal of clinical medicine

authors： Varga A,Tilea I,Petra DN,Tilinca MC,Gliga ML,Demian S

更新日期：2020-10-12 00:00:00

abstract：:Injury is a major cause of worldwide child mortality. This retrospective nationwide study aimed to evaluate the characteristics of paediatric injured patients in Japan and their in-hospital mortality trends from 2009 to 2018. Injured patients aged <17 years were enrolled. Data were extracted from the Japan Trauma Data...

journal_title：Journal of clinical medicine

authors： Toida C,Muguruma T,Gakumazawa M,Shinohara M,Abe T,Takeuchi I,Morimura N

更新日期：2020-10-12 00:00:00

abstract：:The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus amygdala and insula retraining (MAIR) compared to a structurally eq...

journal_title：Journal of clinical medicine

authors： Sanabria-Mazo JP,Montero-Marin J,Feliu-Soler A,Gasión V,Navarro-Gil M,Morillo-Sarto H,Colomer-Carbonell A,Borràs X,Tops M,Luciano JV,García-Campayo J

更新日期：2020-10-11 00:00:00

abstract：:While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...

journal_title：Journal of clinical medicine

authors： Bae JK,Kim KI,Lee SH,Yoo MC

更新日期：2020-10-11 00:00:00

abstract：:Branched-chain amino acid (BCAA) and insulin-like growth factor 1 (IGF-1) are essential for muscle protein synthesis. We investigated the association of serum BCAA and IGF-1 levels with sarcopenia and gait speed in 192 patients with liver cirrhosis (LC). Sarcopenia was diagnosed according to the Japan Society of Hepat...

journal_title：Journal of clinical medicine

authors： Saeki C,Kanai T,Nakano M,Oikawa T,Torisu Y,Saruta M,Tsubota A

更新日期：2020-10-10 00:00:00

abstract：:Customized cross-linking has been proposed as an alternative to conventional cross-linking in patients with progressive keratoconus, targeting greater flattening of the cone region and improved visual function. Epithelium-on cross-linking aims to reduce complications associated with epithelial removal, while the addit...

journal_title：Journal of clinical medicine

authors： Kamiya K,Kanayama S,Takahashi M,Shoji N

更新日期：2020-10-08 00:00:00

abstract：:In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not only the process of carcinogenesis through cancer-related inflammation mechanisms, but also tumor progression, invasion, and metastasis. In particular, tumor-associated macrophages (TAMs) are the most abundant leucocyte sub...

journal_title：Journal of clinical medicine

authors： Belgiovine C,Digifico E,Anfray C,Ummarino A,Torres Andón F

更新日期：2020-10-08 00:00:00

abstract：:Previous studies have shown better clinical outcomes after total hip arthroplasty (THA) compared to hemiarthroplasty (HA) for displaced femoral neck fracture. However, few studies have focused on the surgical risks of the two procedures. Therefore, we investigated the perioperative complications of HA and THA in femor...

journal_title：Journal of clinical medicine

authors： Ogawa T,Yoshii T,Moriwaki M,Morishita S,Oh Y,Miyatake K,Nazarian A,Shiba K,Okawa A,Fushimi K,Fujiwara T

更新日期：2020-10-03 00:00:00

abstract：BACKGROUND:Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte r...

journal_title：Journal of clinical medicine

authors： Lee SC,Kim SJ,Yu MH,Lee KJ,Cha YS

更新日期：2020-10-01 00:00:00

abstract：:Prediction of recurrences after catheter ablation of atrial fibrillation (AF) remains challenging. We sought to investigate the long-term outcomes after AF catheter ablation. A total of 2221 consecutive patients who underwent catheter ablation for symptomatic AF were included in this study (mean age 55 ± 11 years, 20....

journal_title：Journal of clinical medicine

authors： Baek YS,Choi JI,Kim YG,Lee KN,Roh SY,Ahn J,Kim DH,Lee DI,Hwang SH,Shim J,Kim JS,Kim DH,Park SW,Kim YH

更新日期：2020-09-30 00:00:00

abstract：INTRODUCTION:Advances in the acute treatment of myocardial infarction (AMI) substantially reduced in-hospital mortality, but the post-discharge prognosis is still unacceptable. The Managed Care in Acute Myocardial Infarction (MC-AMI) is a program of Poland's National Health Fund that aims at comprehensive post-AMI care...

journal_title：Journal of clinical medicine

authors： Wita K,Kułach A,Sikora J,Fluder J,Nowalany-Kozielska E,Milewski K,Pączek P,Sobocik H,Olender J,Szela L,Kalarus Z,Buszman P,Jankowski P,Gąsior M

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal mus...

journal_title：Journal of clinical medicine

authors： Kukla M,Skladany L,Menżyk T,Derra A,Stygar D,Skonieczna M,Hudy D,Nabrdalik K,Gumprecht J,Marlicz W,Koulaouzidis A,Koller T

更新日期：2020-09-29 00:00:00

abstract：:Epistaxis is a common debilitating manifestation in hereditary hemorrhagic telangiectasia (HHT), due to mucocutaneous telangiectases. The epistaxis can be difficult to control despite available treatments. Dysregulated angiogenesis has been shown to be associated with telangiectases formation. Topical propranolol has ...

journal_title：Journal of clinical medicine

authors： Mei-Zahav M,Gendler Y,Bruckheimer E,Prais D,Birk E,Watad M,Goldschmidt N,Soudry E

更新日期：2020-09-28 00:00:00

abstract：:Objectives: One of the challenges of spine surgery is the need for adequate exposure of the anterolateral spinal column. Improved retractor systems with integrated lighting minimize the need for large thoracotomy, flank, or abdominal incisions. In 2013, we began using the NuVasive MaXcess® system via a minimal-access ...

journal_title：Journal of clinical medicine

authors： Khan-Makoid S,Tjaden BL Jr,Leake SS,McFall RG,Miller CC 3rd,Sandhu HK,Schmitt K,Charlton-Ouw KM

更新日期：2020-09-27 00:00:00

abstract：:To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older p...

journal_title：Journal of clinical medicine

authors： Lee HS,Park KW,Kang J,Ki YJ,Chang M,Han JK,Yang HM,Kang HJ,Koo BK,Kim HS

更新日期：2020-09-27 00:00:00

abstract：:Cardiogenic shock (CS), as the most severe form of heart failure, is associated with very high mortality rates despite therapeutic advances in the last decades. Gender differences in outcomes have been widely reported regarding several cardiovascular diseases. The aim of our study was to evaluate potential gender disp...

journal_title：Journal of clinical medicine

authors： Jerónimo A,Ferrández-Escarabajal M,Ferrera C,Noriega FJ,Diz-Díaz J,Fernández-Jiménez R,McInerney A,Fernández-Ortiz A,Viana-Tejedor A

更新日期：2020-09-27 00:00:00

abstract：:Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It has been identified as one of the most common comorbidities associated with femoral neck fracture (FNF). The aim of this review was to evaluate the impact of physical therapy on FNF patients' ...

journal_title：Journal of clinical medicine

authors： Avola M,Mangano GRA,Testa G,Mangano S,Vescio A,Pavone V,Vecchio M

更新日期：2020-09-26 00:00:00

abstract：:A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful and unsuccessful uvulopalatopharyngoplasty (UPPP). This retrospective...

journal_title：Journal of clinical medicine

authors： Tsou YA,Chou EC,Shie DY,Lee MJ,Chang WD

更新日期：2020-09-25 00:00:00

abstract：OBJECTIVE:In order to promote physical activity (PA) in patients with complicated type 2 diabetes, a better understanding of daily movement is required. We (1) objectively assessed PA in patients with type 2 diabetes, and (2) studied the association between muscle mass, dietary protein intake, and PA. Methods: We perfo...

journal_title：Journal of clinical medicine

authors： Hagedoorn IJM,den Braber N,Oosterwijk MM,Gant CM,Navis G,Vollenbroek-Hutten MMR,van Beijnum BF,Bakker SJL,Laverman GD

更新日期：2020-09-25 00:00:00

abstract：:Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of rare immune-mediated diseases associated with cancer. The aim of this study was to investigate the prevalence of PNSs in the province of Brescia. PNS prevalence was calculated using the Lombardy regional hospital admission records from 1998 to 2...

journal_title：Journal of clinical medicine

authors： Lorusso L,Precone V,Ferrari D,Ngonga GK,Russo AG,Paolacci S,Bertelli M

更新日期：2020-09-25 00:00:00

abstract：:This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...

journal_title：Journal of clinical medicine

authors： Jenneve A,Lorenzo-Villalba N,Courdier G,Talha S,Séverac F,Zulfiqar AA,Arnold P,Lang P,Roul G,Andrès E

更新日期：2020-09-25 00:00:00

abstract：:The present Special Issue of Journal of Clinical Medicine includes a series of important papers that aim to further the evidence base of innovative technological advances in the screening and treatment of mental health, and to further our understanding of their implications for mental health care [...]. ...

journal_title：Journal of clinical medicine

authors： Donker T,Kleiboer A

更新日期：2020-09-24 00:00:00

abstract：:Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ...

journal_title：Journal of clinical medicine

authors： Avazzadeh S,McBride S,O'Brien B,Coffey K,Elahi A,O'Halloran M,Soo A,Quinlan LR

更新日期：2020-09-24 00:00:00

abstract：:This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β-catenin were analyzed using immun...

journal_title：Journal of clinical medicine

authors： Kim D,Kim Y,Lee BB,Kim D,Lee OJ,Jeong P,Kim WJ,Cho EY,Han J,Shim YM,Kim DH

更新日期：2020-09-23 00:00:00

abstract：:Proteins have been demonstrated to reduce food intake in animals and humans via peripheral and central mechanisms. Supplementation of a dietetic regimen with single or mixed amino acids might represent an approach to improve the effectiveness of any body weight reduction program in obese subjects. The aim of the prese...

journal_title：Journal of clinical medicine

authors： Rigamonti AE,Tamini S,Cicolini S,De Col A,Caroli D,Mai S,Rondinelli E,Saezza A,Cella SG,Sartorio A

更新日期：2020-09-22 00:00:00

abstract：:Liver transplantation remains an essential procedure for many patients suffering from alcoholic liver disease. Alcohol use monitoring remains paramount all through the stages of this complex process. Direct alcohol biomarkers, with improved specificity and sensibility, should replace traditional indirect markers. Phos...

journal_title：Journal of clinical medicine

authors： Barrio P,Gual A,Lligoña A,Teixidor L,Weinmann W,Yegles M,Wurst FM

更新日期：2020-09-22 00:00:00

abstract：:Restless legs syndrome (RLS) is highly prevalent among pregnant women. In the present study, a neurological-obstetrical sample of 561 postpartum women was retrospectively screened for RLS symptoms during pregnancy and in the first 12 weeks postpartum. The first screening took place within 1 to 6 days of delivery (T0) ...

journal_title：Journal of clinical medicine

authors： Goecke TW,Schnakenberg P,Frensch M,Chechko N

更新日期：2020-09-21 00:00:00

abstract：:C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development of type 2 diabetes...

journal_title：Journal of clinical medicine

authors： Sokooti S,Kieneker LM,Borst MH,Muller Kobold A,Kootstra-Ros JE,Gloerich J,van Gool AJ,Heerspink HJL,T Gansevoort R,Dullaart RPF,Bakker SJL

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...

journal_title：Journal of clinical medicine

authors： Wild J,Hobohm L,Münzel T,Wenzel P,Steinbrink K,Karbach S,Keller K

更新日期：2020-09-17 00:00:00

abstract：:We evaluated the incidence of temporomandibular disorder (TMD) in patients with rheumatoid arthritis (RA) and examined the association between TMD and RA, through longitudinal follow-up. Population data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 was used. From 514,866 s...

journal_title：Journal of clinical medicine

authors： Byun SH,Min C,Choi HG,Hong SJ

更新日期：2020-09-17 00:00:00

abstract：:The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...

journal_title：Journal of clinical medicine

authors： Savastano MC,Falsini B,Cozzupoli GM,Savastano A,Gambini G,De Vico U,Minnella AM,Placidi G,Piccardi M,Rizzo S

更新日期：2020-09-15 00:00:00